The Binding of Isaac Wiki

Whore of Babylon is an unlockable passive item.

A crescent moon and 5-point star, both black with a red outline.


When Isaac falls to his last half of his last red heart without soul or black hearts, a message reading "What a horrible night to have a curse." appears on the screen and the player becomes the Whore of Babylon.

This increases Isaac's Damage by 2.16 and Speed by 0.36. He will stay in that form until leaving a room with more than a half-heart (soul hearts do not count.) When the player enters a room with the item's effect already activated, the damage increase is 1.5 and the speed increase is 0.3. When activated via III The Empress, increases damage by 3.375 and speed by 0.45 until end of room.

If ??? picks this up, he permanently gains its effects upon leaving the room for the remainder of the game.


  • When the Whore of Babylon is activated, it will give Isaac 3 seconds of invincibility, as opposed to the usual 1 second of invincibility from taking damage (2 seconds from full heart damage). This can be used to get free Coins from Blood Donation Machines when Whore of Babylon activates.
  • If Isaac takes a full heart damage with only one heart remaining, he will die and Whore of Babylon will not activate.


  • Any items that give Isaac Flight (with the exception of Spirit Of The Night) will also give him black wings, if the player has the Whore of Babylon. This also applies to any Devil Room item that turns Isaac black/demonic, such as The Pact or Brimstone.
  • The Dead Bird does not spawn upon Whore of Babylon's activation, assuming no damage was taken before in the room.


  • Guppy's Paw - Helps the player to reduce the amount of normal health to increase the chance to trigger the transformation.
  • IV Bag, Razor Blade, Blood Rights or Kamikaze - These items require a health payment in order to be used, thus helping the player trigger Whore Of Babylon more often while also preserving soul hearts.



  • The message that is displayed when the item takes effect is a reference to Castlevania 2: Simon's Quest.
  • The item's appearance is similar to the Curse Room symbol, as shown on the minimap.
  • The biblical Whore of Babylon is mentioned in the book of revelations 17:4-18. While the meaning is debated, the Whore is one of the figures relating to the end of the world associated with the Antichrist and Beast of Revelation. She is the epitome of the concept of sexuality as a form of evil, following from Eve as the root of that sin, which is why Eve starts with the potential to become the Whore.
  • The item's symbol also resembles the backwards symbol of Islam.
Passive Items Tear Modifiers: The Inner EyeSpoon BenderMy ReflectionSkatoleCube of MeatCupid's ArrowDr. FetusMom's EyeWiggle WormTechnologyChocolate MilkLoki's HornsLittle ChubbySpider's BiteThe Common ColdThe ParasiteMom's ContactsMom's KnifeOuija BoardBrimstoneA Lump of Coal

(Wrath of the Lamb DLC: IPECACTough LoveTechnology 2Mutant SpiderEpic FetusPolyphemusSacred Heart)

Stat Ups: The Sad OnionMax's HeadNumber OneBlood of the MartyrMagic MushroomRoid RageRaw LiverLunchDinnerDessertBreakfastRotten MeatWooden SpoonThe BeltMom's UnderwearMom's HeelsMom's LipstickWire Coat HangerStevenPentagramThe MarkGrowth HormonesMini MushroomThe PactSmall RockSuper BandageRobo-BabyLittle C.H.A.D.Little GishLittle SteveThe RelicThe HaloMoney Equals PowerBlood BagOdd Mushroom (Thin)Odd Mushroom (Large)Whore Of BabylonBucket Of Lard
(Wrath of the Lamb DLC: StigmataSpeed BallChemical PeelBloody LustCat-O-Nine-TailsStem CellsTooth PicksSMB Super Fan!MEAT!Magic 8 BallSqueezyJesus Juice)

Familiars and Orbitals: Brother BobbyHalo Of FliesDistant AdmirationSister MaggyGuardian AngelDemon BabyDead BirdForever AloneSack Of PenniesBomb Bag
(Wrath of the Lamb DLC: Bum FriendThe PeeperGhost BabyHarlequin BabyDaddy LonglegsSacrificial DaggerRainbow BabyHoly WaterGuppy's Hair BallAbel)

Others: 1UPThe VirusLess Than ThreeSkeleton KeyA DollarA QuarterBoom!TranscendenceThe CompassPHDRosaryXRay VisionLucky FootMagnetoTreasure MapThe LadderCharm Of The VampireThe BatterySteam SaleDead CatLord Of The PitSpelunker HatMr. MegaThe Wafer9 VoltBobby-Bomb
(Wrath of the Lamb DLC: Guppy's TailMom's PurseBob's CursePageant BoyScapularInfestationThe MulliganHabitSpirit Of The NightAnkhCeltic CrossMitreFateThe Black BeanHoly GrailDead DovePyro3 Dollar BillMom's Coin PurseBox)

Activated Items Base Items: The PoopMr. BoomTammy's HeadMom's BraKamikazeMom's PadBob's Rotten HeadTeleport!My Little UnicornYum HeartDoctor's RemoteShoop Da Whoop!Lemon MishapThe HourglassThe NailWe Need To Go Deeper!Deck of CardsMonstro's ToothThe GamekidMom's Bottle of PillsThe DiceThe Pinking ShearsThe BeanDead Sea ScrollsRazor BladeForget Me NowA Pony

(Wrath of the Lamb DLC: Guppy's PawIV BagBest FriendRemote DetonatorGuppy's HeadPrayer CardNotched AxeCrystal BallCrack The SkyThe CandleD20Spider ButtDad's KeyPortable SlotWhite PonyBlood Rights)

Books: The BibleThe Book of BelialThe NecronomiconBook Of RevelationsBook of ShadowsAnarchist CookbookThe Book Of SinMonster Manuel
(Wrath of the Lamb DLC: Telepathy for Dummies)