Monster
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Description
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WotL DLC
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Fat Fly
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Alternate version of Pooters. Fires 2 shots in a V-formation and does not deal touch damage.
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✔
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Spit
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Flies slowly towards Isaac, exploding into an IPECAC shot upon death which targets other Spits in the room, or Isaac.
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✔
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Spider
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Moves erratically around the room, damaging Isaac by touch.
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✔
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Big Spider
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Moves erratically around the room, splitting into two Spiders upon death.
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✔
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Gazing Globin
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Quickly walks towards Isaac, dealing one heart of contact damage. Turns into a pile of goo and slides away after taking enough damage, where it can be killed. Will regenerate after a short amount of time if not killed quickly.
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Mask + Heart
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Invulnerable mask with a slow-moving Heart. Functions similarly to a Knight. The Heart fires 4 blood shots in a plus pattern when Isaac gets near. Killing the Heart will automatically kill the Mask.
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✔
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Clotty
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Moves around the room, firing 4 blood shots in a plus pattern.
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Clot
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Moves around the room, firing 4 tar shots in an X pattern.
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Brain
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Crawls around the room, leaving a trail of red Creep that does one heart of damage.
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Guts
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Attaches itself to a wall or obstacle, such as a Rock, rolling around the room.
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Mama Guts
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Slowly moves around the room, occassionally hopping and firing 8 large blood shots in all directions. Will split into 2 Guts upon death.
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✔
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Para-Bite
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Moves towards Isaac. Can burrow underground and reappear elsewhere.
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Fred
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Fires an IPECAC shot at Isaac. Will hop out of the ground and burrow elsewhere, firing 4 blood shots in an X pattern while doing so.
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Lump
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Fires 3 fast-moving blood shots at Isaac when he gets in its line of sight. Will burrow underground and reappear elsewhere after firing its shots.
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Leech
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Quickly charges towards Isaac when he gets in its line of sight.
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Kamikaze Leech
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Quickly charges towards Isaac when he gets in its line of sight. Explodes with a large blast radius upon death.
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Holy Leech
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Quickly charges towards Isaac when he gets in its line of sight. Explodes with a large blast radius upon death. Has an Eternal Fly circling it.
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✔
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Double Vis
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Charges up a Brimstone laser which fires from both sides when Isaac gets in its line of sight.
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✔
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Eye
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Quickly fires a Technology-like laser at Isaac.
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Bloodshot Eye
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Quickly fires a Brimstone-like laser at Isaac.
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Dople
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Copies Isaac's movements, and fires tears at the same time as him.
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Evil Twin
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Copies Isaac's movements, and fires tears at the same time as him.
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Baby
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Fires a single blood shot at Isaac. Can teleport and reappear elsewhere.
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Angelic Baby
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Fires 3 blood shots at once at Isaac, has much more health than regular Babies.
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✔
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Vomit Grimace
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Stationary and invulnerable monster that fires an IPECAC shot at Isaac. Stops firing when room is cleared.
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✔
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Minibosses (7 Sins) found in normal rooms:
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Wrath
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Usually paired with another Wrath. Fires Bombs at Isaac that detonate after a short amount of time, in a manner similar to Dr. Fetus.
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Sloth
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Usually paired with another Sloth. Fires IPECAC shots at Isaac, while occasionally spawning Chargers
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Envy
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Usually paired with another Envy. Moves around the room slowly at first, and then splits into two faster-moving heads after taking enough damage. These heads will split into two more heads with a smaller size and increased speed after taking enough damage, which will then split into the smallest heads that do not split.
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Bosses found in normal rooms:
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Blastocyst
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Hops around the room, firing 4 large blood shots in a + pattern. Splits into two smaller parts upon taking enough damage, and into an Embyro at the end.
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Gemini
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Two joined twins that compose 50% of the health bar each. The large twin runs towards Isaac, while the smaller twin fires fast-moving blood shots. The smaller twin will stop firing blood shots upon the larger twin's death, and instead start chasing Isaac.
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Fistula
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Floats around the room diagonally, splitting into smaller, faster versions every time it takes damage. Smallest versions spawn a Charger when killed.
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Gurdy Jr.
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Spawns Pooters regularly, and can fire blood shots in all 8 directions. Will occasionally charge towards Isaac at very high speeds, bouncing off walls.
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✔
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The Husk
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Moves around the room diagonally, spawning Flies and firing a large number of blood shots in short intervals.
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✔
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The Hollow
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Two multi-segmented enemies that fly around the room diagonally, damaging Isaac by contact. All of the segments have to be destroyed for the boss to be killed.
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✔
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Loki
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Constantly fires 4 blood shots in a plus or cross pattern, and sometimes in all 8 directions at once. Occasionally teleports around the room. Can spawn Boom Flies
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