Isaac RebirthKeeper sprite

Uriel (ウリエル Urieru) is a secret unlockable boss fight, accessible after defeating the The Lamb in the Dark Room or ??? in The Chest. After one of these requirements is fulfilled, this boss can be initiated at any point in an Angel Room by planting a bomb near the angel statue or destroying it through other means.

Upon defeat, Uriel will drop Key Piece 1, required to unlock the large door at the start of The Chest or Dark Room. The defeat of two Angels will also unlock the item Dad's Key.


  • Moves towards Isaac.
  • Fires 5 blood tears in a circular manner.
  • Shoots a single beam of light straight downward, or 2 beams diagonally downwards.


  • Because the Angel battle will always be initiated whenever an angel statue is destroyed, Angels can be confronted more than once in a single playthrough. The battle can still be initiated after both pieces of the key are collected, though defeating them after this will yield no additional items aside from a normal pick-up.


  • Uriel is one of the archangels of Christianity, and only mentioned from the Apocrypha of the Bible. Uriel means "God is my light".

Regular Bosses
BlastocystChubDaddy Long LegsDark OneDingleDuke of FliesThe FallenFistulaGeminiGurdyGurdy Jr.GurglingsThe HauntLarry Jr.LokiMama GurdyMask of InfamyMega FattyMega MawMonstroMr. FredPeepPinPolycephalusScolexTurdlingsWidow

Afterbirth: BrownieDangleLittle HornRag ManTurdlings
Afterbirth †: Big HornRag Mega
Antibirth-only: Baby PlumBeelzeblubChimeraGreat GideonHornfelThe RainmakerReap CreepRotgutThe ScourgeThe SirenTuff TwinsWormwood

Posthumous Bosses
The AdversaryThe Blighted OvumThe BloatThe CageCarrion QueenThe GateThe HollowThe HuskLokiiMonstro IITeratomaThe Wretched

Afterbirth: The ForsakenThe FrailThe Stain
Antibirth-only: The HereticThe PileThe Visage

Alternative Bosses

Afterbirth †: Sisters Vis

ConquestWarFamineDeathPestilenceHeadless Horseman
Final Bosses
???IsaacIt LivesThe LambMega SatanMomMom's HeartSatan

Afterbirth: HushUltra Greed
Afterbirth †: Delirium
Antibirth-only: The Witness

Seven Deadly Sins
Seven Super Deadly Sins
Super EnvySuper GluttonySuper GreedSuper LustSuper PrideSuper SlothSuper WrathUltra Pride
Angels / Demons
KrampusGabrielUrielFallen Angels
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