Isaac RebirthKeeper sprite

Uriel (ウリエル Urieru) is a secret unlockable boss fight, accessible after defeating the The Lamb in the Dark Room or ??? in The Chest. After one of these requirements is fulfilled, this boss can be initiated at any point in an Angel Room by planting a bomb near the angel statue or destroying it through other means.

Upon defeat, Uriel will drop Key Piece 1, required to unlock the large door at the start of The Chest or Dark Room. The defeat of two Angels will also unlock the item Dad's Key.


  • Moves towards Isaac.
  • Fires 5 blood tears in a circular manner.
  • Shoots a single beam of light straight downward, or 2 beams diagonally downwards.


  • Because the Angel battle will always be initiated whenever an angel statue is destroyed, Angels can be confronted more than once in a single playthrough. The battle can still be initiated after both pieces of the key are collected, though defeating them after this will yield no additional items aside from a normal pick-up.


  • Uriel is one of the archangels of Christianity, and only mentioned from the Apocrypha of the Bible. Uriel means "God is my light".
The Binding of Isaac / Rebirth
Regular bosses Original: BlastocystChubDuke of FliesThe FallenFistulaGeminiGurdyLarry Jr.LokiMonstroPeepScolex
(Wrath of the Lamb: Daddy Long LegsGurdy Jr.Mask of InfamyPinWidow)

Rebirth: Dark OneDingleGurglingsThe HauntMama GurdyMega FattyMega MawMr. FredPolycephalus
(Afterbirth: BrownieDangleLittle HornRag ManTurdlings)
(Afterbirth †: Big HornRag Mega)

Posthumous Bosses Original: Monstro II
(Wrath of the Lamb: The Blighted OvumThe BloatCarrion QueenThe HollowThe HuskLokiiTeratomaThe Wretched)

Rebirth: The AdversaryThe CageThe Gate
(Afterbirth: The ForsakenThe FrailThe Stain)

Alternative Bosses Original: C.H.A.D.GishSteven
(Wrath of the Lamb: Triachnid)

Rebirth: Sisters Vis (Afterbirth †)

Harbingers Original: WarFamineDeathPestilenceHeadless Horseman

(Wrath of the Lamb: Conquest)

Final Bosses Original: It LivesMomMom's HeartSatan
(Wrath of the Lamb: ???Isaac)

Rebirth: The LambMega Satan
(Afterbirth: HushUltra Greed)
(Afterbirth †: Delirium)

Seven Deadly Sins EnvyGluttonyGreedLustPrideSlothWrath
Seven Super Deadly Sins Super EnvySuper GluttonySuper GreedSuper LustSuper PrideSuper SlothSuper WrathUltra Pride
Angels / Demons Original: Krampus

Rebirth: GabrielUrielFallen Angels

The Legend of Bum-bo
Regular bosses BygoneDuskGibsGizzardaLoafPeeperPyreSangreShy GalThe Duke
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