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Keeper sprite

The Stain (ザ・ステイン Za Sutein) is a boss added to the Afterbirth DLC. It is the posthumous version of Polycephalus.

Though being a pile of guts with 3 skulls and flesh slightly growing over them, looking at the bottom of one of the head's mouth, you will see it looks like a horseshoe.

The Binding of Isaac Afterbirth "The Stain" boss fight

The Binding of Isaac Afterbirth "The Stain" boss fight


Bosses
Bosses
Regular Bosses
BlastocystChubDaddy Long LegsDark OneDingleDuke of FliesThe FallenFistulaGeminiGurdyGurdy Jr.GurglingsThe HauntLarry Jr.LokiMama GurdyMask of InfamyMega FattyMega MawMonstroMr. FredPeepPinPolycephalusScolexTurdlingsWidow

Afterbirth: BrownieDangleLittle HornRag ManTurdlings
Afterbirth †: Big HornRag Mega
Antibirth-only: Baby PlumBeelzeblubChimeraGreat GideonHornfelThe RainmakerReap CreepRotgutThe ScourgeThe SirenTuff TwinsWormwood

Posthumous Bosses
The AdversaryThe Blighted OvumThe BloatThe CageCarrion QueenThe GateThe HollowThe HuskLokiiMonstro IITeratomaThe Wretched

Afterbirth: The ForsakenThe FrailThe Stain
Antibirth-only: The HereticThe PileThe Visage

Alternative Bosses
C.H.A.D.GishStevenTriachnid

Afterbirth †: Sisters Vis

Harbingers
ConquestWarFamineDeathPestilenceHeadless Horseman
Final Bosses
???IsaacIt LivesThe LambMega SatanMomMom's HeartSatan

Afterbirth: HushUltra Greed
Afterbirth †: Delirium
Antibirth-only: The Witness

Mini-bosses
Seven Deadly Sins
EnvyGluttonyGreedLustPrideSlothWrath
Seven Super Deadly Sins
Super EnvySuper GluttonySuper GreedSuper LustSuper PrideSuper SlothSuper WrathUltra Pride
Angels / Demons
KrampusGabrielUrielFallen Angels
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