The Depths

The Depths is the third chapter the player encounters. It takes the shape of a greyish stone cave, littered with bones.

Rooms

• 1: The room will always appear once in this floor
• 2: The room will always appear twice in this floor
• Possible: There is a chance for this room to appear, usually due to certain criteria being met
• *: This room can only appear due to a bug or special item
• -: The room cannot appear in this floor.

Rooms with the core game
Rooms	The Depths 1	The Depths 2	The Depths XL	Note
Regular Rooms	10 - 12	14 - 15	21 - 31	The player must have Wrath of the Lamb installed for The Depths XL to appear.
Treasure Room	1	1	2
Shop	1	1	1	There is always one shop, even in XL floors.
Secret Room	1	1	1
Boss Room	1	1	2	Boss Rooms are always linked in XL floors.
Challenge Room	Possible	Possible	Possible	Will only be generated if Isaac has full health while entering the floor.
Arcade	-	Possible	Possible	Only generated when Isaac has 5 Coins upon entering a new floor or part.
Devil Room	Possible	Possible	Possible	After fighting Mom, a Devil Room can appear and the sound will still play, but it is not possible to enter it as no door will appear. Using The Joker Card or teleporting out of the Boss Room and re-entering will allow you to enter the room.
I AM ERROR	Possible	Possible	Possible	Only reachable by using the Telepills, which have a 6.66% chance to teleport Isaac to this room.
Rooms with Wrath of the Lamb
Rooms	The Depths 1	The Depths 2	The Depths XL	Note
Super Secret Room	1	1	1
Curse Room	Possible	Possible	Possible
Sacrifice Room	Possible	Possible	Possible
Angel Room	Possible	*	*	After fighting Mom, an Angel Room can appear and the sound will still play, but it is not possible to enter it as no door will appear. Using The Joker Card or teleporting out of the Boss Room and re-entering will allow you to enter the room.
Library	Possible	Possible	Possible	5% base chance to spawn, 25% if Isaac is holding a book.
Boss Challenge Room	Possible	Possible	Possible

Monsters

Monster	Description	WotL DLC
Attack Fly	Red Flies that follow Isaac and deal touch damage.
Moter	Follows Isaac, similar to Attack Flies. Will split into 2 Attack Flies upon death.
Pooter	Slow-moving flies that fire single blood shots at Isaac. Pooters do not deal touch damage.
Boom Fly	Flies around the room diagonally, dealing touch damage and exploding with a large blast radius upon death.
Boil	Stationary enemy that shrinks upon being hit. Will quickly swell up if not killed in time. Fires multiple short-ranged blood projectiles when fully swollen.
Hive	Walks around the room, avoiding Isaac while spawning Attack Flies. Spawns a large number of Flies upon death.
Leaper	Jumps around the room quickly, but not as fast as F. Hoppers. Occasionally jumps high into the air, dropping down elsewhere while firing 4 blood shots in a plus pattern.
Mr. Maw	Walks towards Isaac, quickly launching its head, still attached to its body by a cord. Turns into a Maw or Pacer upon death.
Globin	Walks towards Isaac, dealing one heart of contact damage. Turns into a pile of goo after taking enough damage, where it can be killed. Will regenerate after a short amount of time if not killed quickly.
Gazing Globin	Quickly walks towards Isaac, dealing one heart of contact damage. Turns into a pile of goo and slides away after taking enough damage, where it can be killed. Will regenerate after a short amount of time if not killed quickly.
Knight	Moves erratically around the room. Can only be damaged from behind.
Selfless Knight	Moves erratically around the room, charging at Isaac at very high speed. Can only be damaged from behind.
Brain	Crawls around the room, leaving a trail of red Creep that does one heart of damage.
Guts	Attaches itself to a wall or obstacle, such as a Rock, rolling around the room.
Leech	Quickly charges towards Isaac when he gets in its line of sight.
Host	Invulnerable stationary enemy. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Upon raising its head, it will fire 3 blood shots and lower its head again.
Red Host	Stationary enemy that can be damaged even when its head is lowered. Fires 5 blood shots instead of 3 when rising, and fires more frequently.
Vis	Charges up a Brimstone laser when Isaac gets in its line of sight.
Baby	Fires a single blood shot at Isaac. Can teleport and reappear elsewhere.
Stone Grimace	Stationary and invulnerable monster that fires a fast-moving blood shot at Isaac. Stops firing when room is cleared.
Vomit Grimace	Stationary and invulnerable monster that fires an IPECAC shot at Isaac. Stops firing when room is cleared.	✔
Bosses found in normal rooms:
Blastocyst	Hops around the room, firing 4 large blood shots in a + pattern. Splits into two smaller parts upon taking enough damage, and into an Embyro at the end.
Larry Jr.	Multi-segmented enemy that quickly crawls around the room, not targeting Isaac. Constantly leaves trails of Poop.
Fistula	Floats around the room diagonally, splitting into smaller, faster versions every time it takes damage. Smallest versions spawn a Charger when killed.
Chub	Moves around the room randomly, charging at Isaac if he gets in her line of sight. Constantly spawns Chargers.

Bosses

Monstro II

Loki

War (Horseman of the Apocalypse)

Gish (Monstro II's Alt)

Mom (Final boss of The Depths)

Room-Layouts

5 soul hearts after defeating mom (2 were from the Squeezy item).

Battling the Maw. Note the Eternal Fly buzzing around the enemy.

Battling the blue champion variant of Mom.

Battling the red champion variant of Mom.

Battling against Mom's spawns.

Related Achievements

"I Killed Mom!" - Defeat Mom in The Depths 2.
"Loki's Horns" - Defeat all of the bosses in The Depths. (Monstro II, Loki, Mom)
"Dark Boy" - Complete The Depths without taking damage.

Chapters
Chapter 1	Chapter 2	Chapter 3	Chapter 4	Chapter 5	Chapter 6
The Basement The Cellar	The Caves The Catacombs	The Depths Necropolis	The Womb Utero	Sheol Cathedral	The Chest