- For other uses, see Spider (disambiguation).
- It wanders around aimlessly and allows Isaac to see tear damage points and the health bars of all enemies.
- One thing that many people don't notice about Spider Mod is that it can inflict various status effects from passive items to enemies. These status effects include: Poison, Charming, Slowness, Fearing and more to be discovered.
- This familiar is a reference to Spidermod, a modification to the original Binding of Isaac game; made by one of the lead Rebirth developers Spider853. One feature of Spidermod was to show damage numbers on screen.
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