Keeper sprite

Serpent's Kiss is an unlockable passive item added to the Afterbirth DLC for The Binding of Isaac: Rebirth.


  • Gives Isaac a chance to shoot poison tears.
  • Poisons enemies that make contact with Isaac.
  • Enemies affected by the poison have a chance of dropping black hearts.


  • Athame: The black ring triggered by Athame applies the Serpent's Kiss' poison. Enemies killed by the ring will have an increased chance to drop black hearts.
  • Invulnerability: Contact while invincible deals poison damage.
  • Scorpio: Grants a 100% chance of poison tears.
  • Second Hand: Increases the duration of the poison.
  • Soy Milk: Increases the chance of enemies and bosses being poisoned due to the low damage and high fire rate.
  • The Common Cold: Adds to the chance of firing poison tears, the chance increasing with Isaac's luck.
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