Roid Rage is a passive item.
A syringe with a green substance inside.
Isaac's expression appears aggressive. He smiles wide, revealing disorderly and jagged teeth. A "vein" is shown on his forehead.
Although the pickup quote claims that the item increases both speed and range, the item only increases Speed by 0.6.
- Flight - Being able to fly will allow much easier control of Isaac due to his high speed.
- This item's name, appearance and effect are taken from an item from The C Word, another of Edmund McMillen's games.
- Roid Rage is a term for aggressive behavior caused by the abuse of steroids.
- The Common Cold - Collect two of the following items in one playthrough: Roid Rage, The Virus, or Growth Hormones.