Isaac RebirthKeeper sprite

Polycephalus (ポーリセファラス Pōrisefarasu) is a boss that can appear in the Catacombs and The Womb as a normal enemy from The Binding of Isaac: Rebirth.


Polycephalus is probably the most disturbing-looking boss in the game. It appears as a mass of undeveloped fetuses melded together from a giant half buried one (with total four heads). Each heads possess with empty eye-sockets streaming with bloody tears. It also appears to have several arms.


Polycephalus have few types of attack patterns, however before performing any of them it will burrow under the ground and become invulnerable, then burst out of ground and attack.

  • Spray out a barrage of blood shots towards the character in a similar fashion as Monstro.
  • Fire a spread-shot of 3 shots towards the character.
  • Summon a Round Worm.
  • Fire 8-directional shots.

Notice that the sound he makes before using each attack is different.

Polycephalus can not pop up right below the character; It usually appears in front of it. By standing still and shooting at it right after it appears will quickly finish the battle.

Champion Variants

Polycephalus receives two champion variants for the Afterbirth DLC.


Coming soon.


Coming soon.


  • "Polycephaly" is the condition of having more than one head.


  • On Catacombs XL, it is possible to fight Polycephalus in both boss fights.

Regular Bosses
BlastocystChubDaddy Long LegsDark OneDingleDuke of FliesThe FallenFistulaGeminiGurdyGurdy Jr.GurglingsThe HauntLarry Jr.LokiMama GurdyMask of InfamyMega FattyMega MawMonstroMr. FredPeepPinPolycephalusScolexTurdlingsWidow

Afterbirth: BrownieDangleLittle HornRag ManTurdlings
Afterbirth †: Big HornRag Mega
Antibirth-only: Baby PlumBeelzeblubChimeraGreat GideonHornfelThe RainmakerReap CreepRotgutThe ScourgeThe SirenTuff TwinsWormwood

Posthumous Bosses
The AdversaryThe Blighted OvumThe BloatThe CageCarrion QueenThe GateThe HollowThe HuskLokiiMonstro IITeratomaThe Wretched

Afterbirth: The ForsakenThe FrailThe Stain
Antibirth-only: The HereticThe PileThe Visage

Alternative Bosses

Afterbirth †: Sisters Vis

ConquestWarFamineDeathPestilenceHeadless Horseman
Final Bosses
???IsaacIt LivesThe LambMega SatanMomMom's HeartSatan

Afterbirth: HushUltra Greed
Afterbirth †: Delirium
Antibirth-only: The Witness

Seven Deadly Sins
Seven Super Deadly Sins
Super EnvySuper GluttonySuper GreedSuper LustSuper PrideSuper SlothSuper WrathUltra Pride
Angels / Demons
KrampusGabrielUrielFallen Angels
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