Isaac RebirthKeeper sprite

Polycephalus (ポーリセファラス Pōrisefarasu) is a boss that can appear in the Catacombs and The Womb as a normal enemy from The Binding of Isaac: Rebirth.


Polycephalus is probably the most disturbing-looking boss in the game. It appears as a mass of undeveloped fetuses melded together from a giant half buried one (with total four heads). Each heads possess with empty eye-sockets streaming with bloody tears. It also appears to have several arms.


Polycephalus have few types of attack patterns, however before performing any of them it will burrow under the ground and become invulnerable, then burst out of ground and attack.

  • Spray out a barrage of blood shots towards the character in a similar fashion as Monstro.
  • Fire a spread-shot of 3 shots towards the character.
  • Summon a Round Worm.
  • Fire 8-directional shots.

Notice that the sound he makes before using each attack is different.

Polycephalus can not pop up right below the character; It usually appears in front of it. By standing still and shooting at it right after it appears will quickly finish the battle.

Champion Variants

Polycephalus receives two champion variants for the Afterbirth DLC.


Coming soon.


Coming soon.


  • "Polycephaly" is the condition of having more than one head.


  • On Catacombs XL, it is possible to fight Polycephalus in both boss fights.
The Binding of Isaac / Rebirth
Regular bosses Original: BlastocystChubDuke of FliesThe FallenFistulaGeminiGurdyLarry Jr.LokiMonstroPeepScolex
(Wrath of the Lamb: Daddy Long LegsGurdy Jr.Mask of InfamyPinWidow)

Rebirth: Dark OneDingleGurglingsThe HauntMama GurdyMega FattyMega MawMr. FredPolycephalus
(Afterbirth: BrownieDangleLittle HornRag ManTurdlings)
(Afterbirth †: Big HornRag Mega)

Posthumous Bosses Original: Monstro II
(Wrath of the Lamb: The Blighted OvumThe BloatCarrion QueenThe HollowThe HuskLokiiTeratomaThe Wretched)

Rebirth: The AdversaryThe CageThe Gate
(Afterbirth: The ForsakenThe FrailThe Stain)

Alternative Bosses Original: C.H.A.D.GishSteven
(Wrath of the Lamb: Triachnid)

Rebirth: Sisters Vis (Afterbirth †)

Harbingers Original: WarFamineDeathPestilenceHeadless Horseman

(Wrath of the Lamb: Conquest)

Final Bosses Original: It LivesMomMom's HeartSatan
(Wrath of the Lamb: ???Isaac)

Rebirth: The LambMega Satan
(Afterbirth: HushUltra Greed)
(Afterbirth †: Delirium)

Seven Deadly Sins EnvyGluttonyGreedLustPrideSlothWrath
Seven Super Deadly Sins Super EnvySuper GluttonySuper GreedSuper LustSuper PrideSuper SlothSuper WrathUltra Pride
Angels / Demons Original: Krampus

Rebirth: GabrielUrielFallen Angels

The Legend of Bum-bo
Regular bosses BygoneDuskGibsGizzardaLoafPeeperPyreSangreShy GalThe Duke
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