Poison is the only effect that occur in the entire The Binding of Isaac game, which commonly affects with most enemies.
A poisoned enemy takes a set number of damage over a certain amount of time. There are eight items that can poison enemies.
Items[]
Each Poison item deals a varying amount of damage over a set time period.
| Item | Icon | Poison Damage | Ticks (Per hit of poison damage) | Total Damage |
|---|---|---|---|---|
| The Common Cold |  |
2 damage | 3 | 6 damage |
| The Virus |  |
3.5 damage | 3 |
10.5 damage (+30 damage upon contact) |
| The Bean |  |
3.5 damage | 10 |
35 damage. (+5 damage upon use) |
| Bad Gas Pill |  |
3.5 damage | 10 |
35 damage. (+5 damage upon use) |
| The Black Bean |  |
3.5 damage | 10 |
35 damage (+5 damage upon contact, in a small area around Isaac) |
| Pinky Eye |  |
4 damage | 3 |
12 damage |
| IPECAC |  |
7 damage | 1 | 7 damage |
| Bob's Curse |  |
7 damage | 7 |
49 damage (+60 flat bomb damage) |
| Bob's Rotten Head |  |
7 damage | 15 |
105 damage (+Variable explosion damage depending on the Damage stat) |
Notes[]
- Isaac's base tears (without any damage modifiers) deal 3.5 damage per hit. Therefore, the average tick of poison damage does damage equivalent to one tear or above.