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For other uses, see Spider (disambiguation).

Mutant Spider is a passive item added in the Wrath of the Lamb DLC.


Each shot fires four tears in a narrow spread. Reduces Tears to minimum, but fire rate can still be increased with items and tears up pills.

The Mutant Spider effectively quadruples your damage, so even a player with low damage can achieve high damage output depending on how many tears hit the target.


  • The Inner Eye - Mutant Spider overrides The Inner Eye.
  • IPECAC - Completely overrides Mutant Spider, nullifying the quad shot effect with no increase to damage.
  • Chemical Peel - Has no effect. However, this DOES work on Cain, as he has a 50% chance of a tear having increased damage. Therefore, multiple Mutant Spider tears can have increased damage.
  • Mom's Knife - Overrides Mutant Spider with increased charge time and no increase in damage.
  • Dr. Fetus - No damage increase, with greatly decreased fire speed.
  • Stem Cells - Distorts shot pattern if Stem Cells are acquired first.


  • Technology - The laser deals tripled damage, but its fire rate is greatly lowered.
  • Technology 2 - The damage of the laser is increased, with the Quad Shot stacking.
  • Polyphemus - The damage bonus will be lowered from (damage+4)*2 to a flat +5 per tear.
  • Tough Love - More than one tear may be a tooth.
  • The Mulligan, Guppy - More attack flies will spawn, due to multiple tears hitting at once.
  • The Parasite - In most cases only one tear will split. 
  • Wiggle Worm - Makes all four tears fire in a waving pattern, which narrows down the spread of Mutant Spider tears.
  • Chocolate Milk - All four tears are charged for additional damage.
  • Brimstone - Overrides Mutant Spider, with tripled damage and the charge time greatly increased.
  • Mom's Eye - Mom's Eye always activates.



Passive Items Tear Modifiers: The Inner EyeSpoon BenderMy ReflectionSkatoleCube of MeatCupid's ArrowDr. FetusMom's EyeWiggle WormTechnologyChocolate MilkLoki's HornsLittle ChubbySpider's BiteThe Common ColdThe ParasiteMom's ContactsMom's KnifeOuija BoardBrimstoneA Lump of Coal

(Wrath of the Lamb DLC: IPECACTough LoveTechnology 2Mutant SpiderEpic FetusPolyphemusSacred Heart)

Stat Ups: The Sad OnionMax's HeadNumber OneBlood of the MartyrMagic MushroomRoid RageRaw LiverLunchDinnerDessertBreakfastRotten MeatWooden SpoonThe BeltMom's UnderwearMom's HeelsMom's LipstickWire Coat HangerStevenPentagramThe MarkGrowth HormonesMini MushroomThe PactSmall RockSuper BandageRobo-BabyLittle C.H.A.D.Little GishLittle SteveThe RelicThe HaloMoney Equals PowerBlood BagOdd Mushroom (Thin)Odd Mushroom (Large)Whore Of BabylonBucket Of Lard
(Wrath of the Lamb DLC: StigmataSpeed BallChemical PeelBloody LustCat-O-Nine-TailsStem CellsTooth PicksSMB Super Fan!MEAT!Magic 8 BallSqueezyJesus Juice)

Familiars and Orbitals: Brother BobbyHalo Of FliesDistant AdmirationSister MaggyGuardian AngelDemon BabyDead BirdForever AloneSack Of PenniesBomb Bag
(Wrath of the Lamb DLC: Bum FriendThe PeeperGhost BabyHarlequin BabyDaddy LonglegsSacrificial DaggerRainbow BabyHoly WaterGuppy's Hair BallAbel)

Others: 1UPThe VirusLess Than ThreeSkeleton KeyA DollarA QuarterBoom!TranscendenceThe CompassPHDRosaryXRay VisionLucky FootMagnetoTreasure MapThe LadderCharm Of The VampireThe BatterySteam SaleDead CatLord Of The PitSpelunker HatMr. MegaThe Wafer9 VoltBobby-Bomb
(Wrath of the Lamb DLC: Guppy's TailMom's PurseBob's CursePageant BoyScapularInfestationThe MulliganHabitSpirit Of The NightAnkhCeltic CrossMitreFateThe Black BeanHoly GrailDead DovePyro3 Dollar BillMom's Coin PurseBox)

Activated Items Base Items: The PoopMr. BoomTammy's HeadMom's BraKamikazeMom's PadBob's Rotten HeadTeleport!My Little UnicornYum HeartDoctor's RemoteShoop Da Whoop!Lemon MishapThe HourglassThe NailWe Need To Go Deeper!Deck of CardsMonstro's ToothThe GamekidMom's Bottle of PillsThe DiceThe Pinking ShearsThe BeanDead Sea ScrollsRazor BladeForget Me NowA Pony

(Wrath of the Lamb DLC: Guppy's PawIV BagBest FriendRemote DetonatorGuppy's HeadPrayer CardNotched AxeCrystal BallCrack The SkyThe CandleD20Spider ButtDad's KeyPortable SlotWhite PonyBlood Rights)

Books: The BibleThe Book of BelialThe NecronomiconBook Of RevelationsBook of ShadowsAnarchist CookbookThe Book Of SinMonster Manuel
(Wrath of the Lamb DLC: Telepathy for Dummies)