Isaac Rebirth

Mr. Fred (MR・フレッド Misutā Fureddo) is a boss found in the Womb or the Utero. He always appears in a double sized room.


Mr. Fred is a giant baby with a medical condition Harlequin Ichthyosis. He has cracked red skin, bulging pupilless eyes, and round lips with four visible teeth. His torso is always visible while his lower part is in underground.


Mr. Fred stays in the center of the room throughout the whole fight, occasionally burrowing underground for brief periods. He will not chase the player.

Mr. Fred has a number of different attacks.

  • Mr. Fred shoots 4 long-range blood tears in the cardinal directions around him. These tears leave red creep and will burst at the end of their range into a larger pool of creep.
  • Mr. Fred burrows underground briefly and pops back up in his original position, firing 8 blood tears around him.
  • Mr. Fred makes a gesture and one of the 4 Homunculus on the side of the room will break free and chase Isaac.
  • He can spawn Fred.


  • While his appearance being based on Harlequin Ichthyosis, Mr. Fred's appearance bears some resemblance to the Harlequin Baby.
  • He is one of the few bosses not to have any champion variants.

Regular Bosses
BlastocystChubDaddy Long LegsDark OneDingleDuke of FliesThe FallenFistulaGeminiGurdyGurdy Jr.GurglingsThe HauntLarry Jr.LokiMama GurdyMask of InfamyMega FattyMega MawMonstroMr. FredPeepPinPolycephalusScolexTurdlingsWidow

Afterbirth: BrownieDangleLittle HornRag ManTurdlings
Afterbirth †: Big HornRag Mega
Antibirth-only: Baby PlumBeelzeblubChimeraGreat GideonHornfelThe RainmakerReap CreepRotgutThe ScourgeThe SirenTuff TwinsWormwood

Posthumous Bosses
The AdversaryThe Blighted OvumThe BloatThe CageCarrion QueenThe GateThe HollowThe HuskLokiiMonstro IITeratomaThe Wretched

Afterbirth: The ForsakenThe FrailThe Stain
Antibirth-only: The HereticThe PileThe Visage

Alternative Bosses

Afterbirth †: Sisters Vis

ConquestWarFamineDeathPestilenceHeadless Horseman
Final Bosses
???IsaacIt LivesThe LambMega SatanMomMom's HeartSatan

Afterbirth: HushUltra Greed
Afterbirth †: Delirium
Antibirth-only: The Witness

Seven Deadly Sins
Seven Super Deadly Sins
Super EnvySuper GluttonySuper GreedSuper LustSuper PrideSuper SlothSuper WrathUltra Pride
Angels / Demons
KrampusGabrielUrielFallen Angels
Community content is available under CC-BY-SA unless otherwise noted.