A bottle of pills with some prescription writing.


Upon activation a random pill will spawn in Isaac's inventory, causing the player to drop their current held Q - slot item, if any. A player will only receive six different pill types in one playthrough.


  • Pill-related Items such as PHD or Lucky Foot (or playing as Cain) are best with this item, as they prevent the player from receiving negative pill effects.
  • As with most Activated Items, Items such as Habit, 9 Volt, and The Battery decrease the charge time, increasing the effectiveness of this item.
  • Works well with Habit, recharging Mom's Pill Bottle by 3 bars every time the player is hit allowing for "pill farming" as with many other activated items.



  • Judging from the title of the item, this can infer that Isaac's mother self medicates with whatever pills she can get her hands on. This might explain her unstable behavior.

Related Achievements

"Mom's Bottle Of Pills" - Use the Blood Donation Machine 20 times. Does not have to be done in a single playthrough.
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