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- For the article about the boss, see Mom.
Issac's mother is the main antagonist of the game's prologue. She was asked by God to sacrifice her own son in order to ultimately prove her love and devotion, causing Issac to retreat to the basement. Isaac's mother, right when she is about to end her son's life in the name of faith, is stopped by divine intervention and Isaac's life is saved.
Not much is known about Isaac's father but there are three photos of him seen during Ending 14. The last image of him is him leaving from Isaac's home.
His name was also mentioned from the item Dad's Key.
| Isaac • Magdalene • Judas • Cain • Eve • Samson • ???|
|Babies • Beggar • Devil Beggar • Key Beggar • Shell Game Beggar • Bomb Bum • Shopkeeper • Others|
|Old Man Keeper|