A red Mushroom with white polka dots.
Isaac becomes larger.
- This item is a reference to Nintendo's Super Mario Bros. series, shown by the colors of the mushroom, and the fact that Isaac grows in size when he picks up the item, much like the mushrooms in the Super Mario Bros. games.
There are a few items that Magic Mushroom can interact with that don't go so well.
- Cricket's Head - 1.5 Multiplier doesn't stack with Magic Mushroom.
Polyphemus - Damage stacks onto Magic Mushroom's multiplier.
The Mark - Stacks.
The Pact - Stacks.
Sacred Heart - Stacks.