The Binding of Isaac Wiki

Xxx form2 Isaac Rebirth

This article refers Isaac as a boss. For the character, see Isaac.
For other uses, see Isaac (disambiguation).

Isaac is a boss added with the Wrath of the Lamb DLC for the original game, and also appears in the Rebirth DLC. He is the game's main character as the final, fixed boss of The Cathedral.


Phase 1

Isaac form1

1st phase.

Isaac will appear lying down in the center of the room, crying on the floor. He shoots 12 high-velocity tears in a radial burst and will retaliate with streams of tears when hit.

Phase 2

Isaac form2

2nd phase.

At 66% of his health, a light will shine on Isaac, and he jumps from the ground. Isaac will then start shooting 4 large purple tears, which home slightly, in all directions. He will still retaliate with some tears when hit.

Phase 3

Isaac form3

3rd phase.

Triggered near 33% of Isaac's health. Isaac will grow angel wings, smile, and start floating. White beams will be randomly shot down from the sky (Similar to Crack The Sky and White Pony), Angel Babies will start spawning frequently (up to a maximum of 6), and the same homing projectiles from before will be shot in six directions at the same time. At this point, Isaac will no longer retaliate with tears when hit.

Champion Variants


Eternal Isaac acts similarly to normal one. But this time he will randomly teleport himself around the room, making it harder to hit him, he sometimes even teleports himself right onto the player. Note that he slowly regenerates HP during Phase 1.


  • Using The Bible during or after the fight will instantly kill the player (Similar to ??? and Satan) unless they have The Wafer item, which will deal 1/2 heart damage instead.
  • Using items with a high fire rate (such as Technology 2) is dangerous in this fight, as Isaac will retaliate with a very large amount of tears upon being hit, unless the player have Mom's Contacts. This also applies to effects which apply damage rapidly, such as Mom's Knife.
  • Applying slow effects such as Little Gish or Spider Bite to Isaac will not affect the speed of his homing tears, but will slow all normal tears.
  • Activating Mom's Bra or triggering the special effect of Mom's Contacts will prevent Isaac from spawning enemies or attacking at all—including when damaged—for the duration of the effect.
  • Isaac cannot be damaged by the Crack The Sky light beams, or by his own. However, any Angelic Babies in the fight can take a small amount of damage from his light beams.
  • It is possible to reduce Isaac to 0 health. If Isaac is on 0 hp, the wings and light will disappear, and Isaac will resume crying on the floor. No projectiles/beams of light will be used (just like when ??? (boss) is reduced to 0 hp). However, any angels spawned from the previous phase will still survive, and will continue to attack the player.


  • The third form is referenced in the Wrath of the Lamb DLC's trailer, which showed Isaac sprouting wings.
  • From both the original game and Rebirth, in phase 1, Isaac makes the same weeping noises as the Mulligan.
  • When Isaac was first added in the initial release of Wrath of the Lamb, his third form only consisted of the rays of light, except with a tremendous rate of firing.
  • From the original game, the picture of Isaac on Isaac's Last Will is identical to that of the Mulligan, but without the bloated head.
  • Isaac smiling at one point during the fight signifies how he's dealt with his unavoidable fate.


  • If the player uses The Hourglass, Isaac will fire blood tears instead of the usual blue tears and purple homing tears.
  • From the original game, if the player is killed by the light beams in the final stage of the battle, the Last Will will display a picture of War.


Standard Bosses Dukeofflies fullThe Duke of FliesGemini fullGemini260x185-400px-Monstro.svgMonstroLarryjr fullLarry Jr.FistulaFistulaGurdy fullGurdyPeep FullPeepChubChubLoki fullLokiScolex fullScolexBlastocyst fullBlastocystTheFallen FullThe Fallen

Wrath of the Lamb DLC: 260x200-400px-Widow3WidowPin cleanPinMask of InfamyMask of InfamyGurdjrGurdy Jr.VS DaddyLonglegsDaddy Long Legs

Posthumous Bosses 285x230-MonstroII fullMonstro II

Wrath of the Lamb DLC: The HuskThe Husk260x220-The Hollow2The Hollow250x200-Teratoma.TeratomaLokii cutoutLokiiBlighted ovumBlighted OvumCarrionqueenThe Carrion QueenThe WretchedThe WretchedBc BloatThe Bloat

Alternate Bosses 287x265-Steven FullsizeStevenChub fullC.H.A.D.Gish fullGish

Wrath of the Lamb DLC: 200x300-400px-Triachnid boss portraitTriachnid

Harbingers 220x287-Isaac Vs famine edited- noobletkFamineBC PestilencePestilenceBC WarWarVSDeathDeath230x200-Headless HorsemanHeadless Horseman

Wrath of the Lamb DLC: BC ConquestConquest

Final Bosses 250x250-400px-MomMomMoms Heart FullMom's Heart250x250-ITLIVEScutoutIt LivesSatan FullSatan

Wrath of the Lamb DLC: Bc isaacIsaacBC xxx???