The Binding of Isaac Wiki

Xxx form2 Isaac Rebirth

Harlequin Baby is an item familiar added to the Wrath of the Lamb DLC for the original game, and in the Rebirth remake. As its name suggests, it appear as a baby with swollen lips, red eyes, and no skin.


Spawns familiar that shoots a pair of blood tears diagonally every second while Isaac is firing.


  • This item is based on a real medical condition named Harlequin Ichthyosis that deforms infants, causing them to have scaly skin, a strangely shaped body, and sunken, red eyes and lips.
  • This familiar looks very similar to Mr. Fred, a boss added to Rebirth.