The Binding of Isaac Wiki

Hard Mode is a mode added to the Eternal Edition update for the original game. It changes the gameplay in certain ways to make it harder. When playing in hard mode, a little pentagram appears on the bottom left of the screen.

  • Rooms contain more advanced enemies and in a higher number.
  • Causes champions to spawn more often, however, they award less consumables.
  • You are less likely to receive a Pickup after completing a room.
  • Bosses no longer drop red hearts when defeating them.
  • You are more likely to be cursed on each floor.
  • You are more likely to receive the harder version of a floor (e.g. Necropolis instead of The Depths)
  • Using the Dice more than once on an item may cause it to disappear as if it was picked up (Vanilla only)
  • Guppy's Paw only grants 2 soul hearts instead of 3 (Vanilla only)
  • You are more likely to drop Eternal hearts.
  • Troll Bombs may disguise as regular bombs and transform on contact.
  • Angel Boss Rooms may appear (indicated by a glowing sword).

In Rebirth, completing Hard Mode will put a red aura over the completion marks on the character selection screen for the character beaten with.