Gabriel (ガブリエル Gaburieru) is a secret unlockable miniboss and one of the angels added in The Binding of Isaac: Rebirth. He is accessible after defeating the The Lamb in the Dark Room or ??? in The Chest for the first time. After one of these requirements is fulfilled, this miniboss can be initiated at any point in an Angel Room by planting a bomb near the angel statue or destroying it through other means.

Upon defeat, Gabriel will drop Key Piece 2, required to unlock the large door at the start of The Chest or Dark Room. Defeating both Angels will also unlock Dad's Key.

In the Afterbirth DLC, along with Uriel, Gabriel can be fought in the Sacrifice Room.


  • Moves towards Isaac.
  • Shoots a ring of 12 blood tears
  • If Gabriel folds his wings, he is about to:
  • If Gabriel's hands start to glow, he is about to fire 4 light beams cardinally



  • Gabriel is an archangel who typically serves as a messenger sent from God to certain people in Christianity. The name means "God is my strength".
    • In Muslim beliefs, Gabriel is the angel who visits Muhammad as he meditates in a cave nearby Mecca.

Regular Bosses
BlastocystChubDaddy Long LegsDark OneDingleDuke of FliesThe FallenFistulaGeminiGurdyGurdy Jr.GurglingsThe HauntLarry Jr.LokiMama GurdyMask of InfamyMega FattyMega MawMonstroMr. FredPeepPinPolycephalusScolexTurdlingsWidow

Afterbirth: BrownieDangleLittle HornRag ManTurdlings
Afterbirth †: Big HornRag Mega
Antibirth-only: Baby PlumBeelzeblubChimeraGreat GideonHornfelThe RainmakerReap CreepRotgutThe ScourgeThe SirenTuff TwinsWormwood

Posthumous Bosses
The AdversaryThe Blighted OvumThe BloatThe CageCarrion QueenThe GateThe HollowThe HuskLokiiMonstro IITeratomaThe Wretched

Afterbirth: The ForsakenThe FrailThe Stain
Antibirth-only: The HereticThe PileThe Visage

Alternative Bosses

Afterbirth †: Sisters Vis

ConquestWarFamineDeathPestilenceHeadless Horseman
Final Bosses
???IsaacIt LivesThe LambMega SatanMomMom's HeartSatan

Afterbirth: HushUltra Greed
Afterbirth †: Delirium
Antibirth-only: The Witness

Seven Deadly Sins
Seven Super Deadly Sins
Super EnvySuper GluttonySuper GreedSuper LustSuper PrideSuper SlothSuper WrathUltra Pride
Angels / Demons
KrampusGabrielUrielFallen Angels
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