Gabriel (ガブリエル Gaburieru) is a secret unlockable miniboss and one of the angels added in The Binding of Isaac: Rebirth. He is accessible after defeating the The Lamb in the Dark Room or ??? in The Chest for the first time. After one of these requirements is fulfilled, this miniboss can be initiated at any point in an Angel Room by planting a bomb near the angel statue or destroying it through other means.

Upon defeat, Gabriel will drop Key Piece 2, required to unlock the large door at the start of The Chest or Dark Room. Defeating both Angels will also unlock Dad's Key.

In the Afterbirth DLC, along with Uriel, Gabriel can be fought in the Sacrifice Room.


  • Moves towards Isaac.
  • Shoots a ring of 12 blood tears
  • If Gabriel folds his wings, he is about to:
  • If Gabriel's hands start to glow, he is about to fire 4 light beams cardinally



  • Gabriel is an archangel who typically serves as a messenger sent from God to certain people in Christianity. The name means "God is my strength".
    • In Muslim beliefs, Gabriel is the angel who visits Muhammad as he meditates in a cave nearby Mecca.
The Binding of Isaac / Rebirth
Regular bosses Original: BlastocystChubDuke of FliesThe FallenFistulaGeminiGurdyLarry Jr.LokiMonstroPeepScolex
(Wrath of the Lamb: Daddy Long LegsGurdy Jr.Mask of InfamyPinWidow)

Rebirth: Dark OneDingleGurglingsThe HauntMama GurdyMega FattyMega MawMr. FredPolycephalus
(Afterbirth: BrownieDangleLittle HornRag ManTurdlings)
(Afterbirth †: Big HornRag Mega)

Posthumous Bosses Original: Monstro II
(Wrath of the Lamb: The Blighted OvumThe BloatCarrion QueenThe HollowThe HuskLokiiTeratomaThe Wretched)

Rebirth: The AdversaryThe CageThe Gate
(Afterbirth: The ForsakenThe FrailThe Stain)

Alternative Bosses Original: C.H.A.D.GishSteven
(Wrath of the Lamb: Triachnid)

Rebirth: Sisters Vis (Afterbirth †)

Harbingers Original: WarFamineDeathPestilenceHeadless Horseman

(Wrath of the Lamb: Conquest)

Final Bosses Original: It LivesMomMom's HeartSatan
(Wrath of the Lamb: ???Isaac)

Rebirth: The LambMega Satan
(Afterbirth: HushUltra Greed)
(Afterbirth †: Delirium)

Seven Deadly Sins EnvyGluttonyGreedLustPrideSlothWrath
Seven Super Deadly Sins Super EnvySuper GluttonySuper GreedSuper LustSuper PrideSuper SlothSuper WrathUltra Pride
Angels / Demons Original: Krampus

Rebirth: GabrielUrielFallen Angels

The Legend of Bum-bo
Regular bosses BygoneDuskGibsGizzardaLoafPeeperPyreSangreShy GalThe Duke
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