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Creep is a fluid produced by various Monsters, Bosses, and Collectables. It affects either Isaac or Monsters and Bosses in certain ways when they come in contact with it, unless they are Flying. All Creep will dissipate after a set amount of time.

Types of Creep

Red Creep

Red Creep is the most common type of Creep, differentiated from regular blood by its glowing nature. It can be left by explosive red projectiles, or a trail behind certain Monsters as they move. Red Creep deals a full heart of damage to Isaac upon touch and is harmless to Monsters and Bosses.

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Bosses Monsters
Blighted ovum.png The Blighted Ovum Brain.png Brain
Super Lust transparent.png Super Lust
230x200-Headless Horseman.png Headless Horseman
Bc Bloat.png The Bloat
Moms Heart Full.png250x250-ITLIVEScutout.png Mom's Heart/It Lives!

Green Creep

Green Creep is functionally identical to Red Creep, damaging Isaac for a full heart when touched and not affecting Monsters or Bosses.

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Bosses
BC Pestilence.png Pestilence
Ultra Pride Edmund.png Ultra Pride
Super Sloth.png Super Sloth

Yellow Creep

Yellow Creep damages Isaac for a half-heart when touched. It is spawned only by the boss Peep.

A beneficial type of yellow Creep can be spawned by using Lemon Mishap, which damages enemies instead of Isaac.

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Bosses Collectables
Peep Full.png Peep Lemon Mishap Icon.png Lemon Mishap

Black Creep

Black Creep deals no damage to Isaac, but slows him down, similar to Cobwebs. Monsters and Bosses however, are unaffected by it.

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Bosses
Gish full.png Gish
Widow Black.png Black champion Widow

White Creep

Added in the Wrath of the Lamb DLC, White Creep deals no damage to Isaac, but slows him down, similar to Cobwebs. Monsters and Bosses however, are unaffected by it.

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Bosses
260x200-400px-Widow3.png Widow
The Wretched.png The Wretched
Pestilence white.png White champion Pestilence

Blue Creep

Blue Creep is a beneficial type of Creep left by the Holy Water item, which activates upon Isaac taking damage. It damages Monsters that come in contact with it and is harmless to Isaac.

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Collectables
Holy Water Icon.png Holy Water
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