Creep is a fluid produced by various Monsters, Bosses, and Collectables. It affects either Isaac or Monsters and Bosses in certain ways when they come in contact with it, unless they are Flying. All Creep will dissipate after a set amount of time.
Types of Creep[]
Red Creep[]
Red Creep is the most common type of Creep, differentiated from regular blood by its glowing nature. It can be left by explosive red projectiles, or a trail behind certain Monsters as they move. Red Creep deals a full heart of damage to Isaac upon touch and is harmless to Monsters and Bosses.
| Left by | |
| Bosses | Monsters |
|---|---|
 The Blighted Ovum
|
 Brain
|
 Super Lust
| |
 Headless Horseman
| |
 The Bloat
| |
  Mom's Heart/It Lives!
| |
Green Creep[]
Green Creep is functionally identical to Red Creep, damaging Isaac for a full heart when touched and not affecting Monsters or Bosses.
| Left by |
| Bosses |
|---|
 Pestilence
|
 Ultra Pride
|
 Super Sloth
|
Yellow Creep[]
Yellow Creep damages Isaac for a half-heart when touched. It is spawned only by the boss Peep.
A beneficial type of yellow Creep can be spawned by using Lemon Mishap, which damages enemies instead of Isaac.
| Left by | |
| Bosses | Collectibles |
|---|---|
 Peep
|
 Lemon Mishap
|
Black Creep[]
Black Creep deals no damage to Isaac, but slows him down, similar to Cobwebs. Monsters and Bosses however, are unaffected by it.
| Left by |
| Bosses |
|---|
 Gish
|
 Black champion Widow
|
White Creep[]
Added in the Wrath of the Lamb DLC, White Creep deals no damage to Isaac, but slows him down, similar to Cobwebs. Monsters and Bosses however, are unaffected by it.
| Left by |
| Bosses |
|---|
 Widow
|
 The Wretched
|
 White champion Pestilence
|
Blue Creep[]
Blue Creep is a beneficial type of Creep left by the Holy Water item, which activates upon Isaac taking damage. It damages Monsters that come in contact with it and is harmless to Isaac.
| Left by | |
| Collectibles | |
|---|---|
 Holy Water
| |