The Binding of Isaac Wiki
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Bosses are major enemies randomly encountered at the end of each chapters from The Binding of Isaac games. Upon death, they drop red hearts and even a passive item. Almost every bosses receive champion variants with different attacks. The posthumous-type bosses are lot stronger than their original counterparts and can only appear in alternative chapters.

Mini-bosses take a role as "minor bosses" and appear randomly every time when entering any rooms. Seven Deadly Sins and their "super" variants are major mini-bosses. Krampus, Uriel, Gabriel, and the Fallen Angels are also mini-bosses and does not relate to the Seven Deadly Sins.

Bosses

Boss Health Champion color(s) Floor(s)

The Binding of Isaac / Wrath of the Lamb

Monstro button
Monstro
250 - Grey
- Pink/red
The Basement
Larry Jr button
Larry Jr.
22 (per segment) - Blue
- Green
The Basement
Gemini button
Gemini
140 (both) - Blue
- Green
The Basement
Duke of Flies button
The Duke of Flies
110 - Green
- Orange
The Basement
The Cellar
Steven button
Steven
140 (both) N/A The Basement
Famine button
Famine
110 Blue The Basement
The Cellar

Mini-bosses

Coming soon.

All items (66)

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