The Binding of Isaac Wiki

Xxx form2 Isaac Rebirth

Cancer is a trinket first added to the Wrath of the Lamb DLC for the original game, and also appear in the Rebirth remake.


  • Decreases tears delay by 2.


  • The effective fire rate increase varies depending on Isaac's current Tears stat. The higher the Tears stat, the higher the percentage increase in fire rate from Cancer. This is because Cancer decreases the time in between each tear by 0.15 seconds.
Bluebaby Soul
???'s Soul
Ace of Spades

Bloody Penny
Burnt Penny Cain's Eye Cancer Child's Heart Counterfeit Penny Cursed Skull
Curved Horn Eve's Bird Foot Flat Penny Fish Head Goat Hoof Isaac's Head Isaac's Fork Judas' Tongue The Left Hand Liberty Cap
Lucky Toe Maggy's Faith Match Stick A Missing Page Mom's Pearl Pinky Eye Push Pin Red Patch Rusted Key Safety Cap
Samson's Lock The Tick Umbilical Cord The Polaroid Game Squid