Brains move around the room slowly, leaving a trail of red Creep that does one full heart of damage to Isaac. They are relatively weak on their own, but can quickly corner Isaac when fought in groups.
Eternal Champion Behavior
Eternal Brain will leave creep and occasionally, shoot a homing blood shot which deals one full heart damage.
- 2 Brains can be spawned after killing MemBrain.
- In the original game, Brains flash in color red for few seconds every time while moving. However, they no longer does so in Rebirth.