Brains are enemies appearing in The Binding of Isaac and the Rebirth remake. They can commonly be found in The Depths and The Womb.
Behavior[]
Brain from the original game.
Brains move around the room slowly, leaving a trail of red Creep that does one full heart of damage to Isaac. They are relatively weak on their own, but can quickly corner Isaac when fought in groups.
Eternal Champion Behavior[]
Eternal Brain will leave creep and occasionally, shoot a homing blood shot which deals one full heart damage.
Notes[]
- 2 Brains can be spawned after killing MemBrain.
Trivia[]
- In the original game, Brains flash in color red for few seconds every time while moving. However, they no longer does so in Rebirth.
| Monsters | ||
|---|---|---|
| Fly variants |  Black Fly •  Attack Fly •  Moter • ( :  Eternal Fly)
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| Gaper variants |  Gaper •  Frowning Gaper •  Mr. Maw • (:  Gurgle)
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| Mulligan variants |  Mulligan •  Mulligoon •  Hive • (:  Mulliboom)
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| Horf variants |  Horf •  Maw •  Red Maw • (:  Psychic Maw)
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| Vis variants |  Vis • (:  Double Vis •  Chubber)
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| Maggot variants |  Maggot •  Charger •  Spitty
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| Hopper variants |  Hopper •  Flaming Hopper •  Leaper
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| Boil variants |  Boil • (:  Gut •  Sack)
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| Clot variants |  Clotty •  Clot •  I. Blob
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| Leech variants |  Leech •  Kamikaze Leech • (:  Holy Leech)
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| Spider variants | :  Spider •  Big Spider •  Trite
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| Pooter variants |  Pooter • (:  Fat Fly)
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| Boomfly variants |  Boom Fly •  Red Boom Fly
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| Pacer variants |  Pacer •  Gusher
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| Sucker variants |  Sucker • (:  Spit)
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| Globin variants |  Globin •  Gazing Globin
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| Knight variants |  Knight •  Selfless Knight
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| Eye variants |  Eye •  Bloodshot Eye
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| Host variants |  Host •  Red Host
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| Baby variants |  Baby • (:  Angelic Baby)
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| Eye variants | Eye • Bloodshot Eye
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| Poky variants |  Poky • (:  Slide)
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| Brain variants |  Brain •  Membrain
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| Gut variants |  Guts • (:  Mama Guts)
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| Dople variants |  Dople •  Evil Twin
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| Grimace variants |  Stone Grimace • (:  Vomit Grimace)
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| Keeper variants | :  Keeper •  Hanger
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| Standalone variants |  Para-Bite •  Fred •  Lump •  Embryo • Peep Eye • (:  Swarmer •  Mask + Heart •  B. Licker)
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