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IsaacHD Isaac Rebirth

Brains are enemies appearing in The Binding of Isaac and the Rebirth remake. They can commonly be found in The Depths and The Womb.

Behavior[]

Brain

Brain from the original game.

Brains move around the room slowly, leaving a trail of red Creep that does one full heart of damage to Isaac. They are relatively weak on their own, but can quickly corner Isaac when fought in groups.

Eternal Champion Behavior[]

Eternal Brain will leave creep and occasionally, shoot a homing blood shot which deals one full heart damage.

Notes[]

  • 2 Brains can be spawned after killing MemBrain.

Trivia[]

  • In the original game, Brains flash in color red for few seconds every time while moving. However, they no longer does so in Rebirth.
Monsters
Fly variants FlyBlack FlyCUSTOMredflyAttack FlyMotersMoter • (Wrath of the Lamb DLC: White flyEternal Fly)
Gaper variants GaperGaperFrowninggaperFrowning GaperShape4336Mr. Maw • (Wrath of the Lamb DLC: Green gaperGurgle)
Mulligan variants MulliganMulliganMulligoonMulligoonHiveHive • (Wrath of the Lamb DLC: MulliboomMulliboom)
Horf variants HorfsHorfMawsMawRedmawRed Maw • (Wrath of the Lamb DLC: PsychicmawPsychic Maw)
Vis variants VisVis • (Wrath of the Lamb DLC: Vis FioDouble VisChubby VisChubber)
Maggot variants MaggotMaggotChargerChargerSpitySpitty
Hopper variants HopperHopperFHopperFlaming HopperLeaperLeaper
Boil variants BoilBoil • (Wrath of the Lamb DLC: Green boilGutWhite boilSack)
Clot variants ClottyClottyClot2ClotBlockadeI. Blob
Leech variants LeechLeechLeech2Kamikaze Leech • (Wrath of the Lamb DLC: Holy leechHoly Leech)
Spider variants Wrath of the Lamb DLC: Black spiderSpiderBig spiderBig SpiderSpider hopperTrite
Pooter variants PouterPooter • (Wrath of the Lamb DLC: SuperpooterFat Fly)
Boomfly variants BoomflyBoom FlySpitflyRed Boom Fly
Pacer variants PacerPacerGusherGusher
Sucker variants SuckerSucker • (Wrath of the Lamb DLC: PufferSpit)
Globin variants GlobinGlobinGlobin 2Gazing Globin
Knight variants KnightsKnightAlternative knightSelfless Knight
Eye variants EyeEyeEye2Bloodshot Eye
Host variants Host1HostHost2Red Host
Baby variants BobyBaby • (Wrath of the Lamb DLC: Angel babyAngelic Baby)
Eye variants EyeEyeEye2Bloodshot Eye
Poky variants PokiesPoky • (Wrath of the Lamb DLC: Spike trapSlide)
Brain variants BrainBrainMembrainMembrain
Gut variants GutsMonsterGuts • (Wrath of the Lamb DLC: Big gutsMama Guts)
Dople variants Dople1DopleDople 2Evil Twin
Grimace variants TurretStone Grimace • (Wrath of the Lamb DLC: VomitTurretVomit Grimace)
Keeper variants Wrath of the Lamb DLC: AvariceKeeperHang manHanger
Standalone variants ParabitePara-BiteFredFredLumpLumpEmbryoEmbryoPeep Eye • (Wrath of the Lamb DLC: SwarmheadSwarmerMask HeartMask + HeartCentipedeB. Licker)
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