Brain

Brains are enemies appearing in The Binding of Isaac and the Rebirth remake. They can commonly be found in The Depths and The Womb.

Behavior

Brains move around the room slowly, leaving a trail of red Creep that does one full heart of damage to Isaac. They are relatively weak on their own, but can quickly corner Isaac when fought in groups.

Eternal Champion Behavior

Eternal Brain will leave creep and occasionally, shoot a homing blood shot which deals one full heart damage.

Notes

• 2 Brains can be spawned after killing MemBrain.

Trivia

• In the original game, Brains flash in color red for few seconds every time while moving. However, they no longer does so in Rebirth.

Monsters
Insects
Black Fly • Attack Fly • Moter • Eternal Fly • Pooter • Fat Fly • Boom Fly • Red Boom Fly • Drowned Boom Fly • Sucker • Spit • Dart Fly • Swarm Fly • Ring Fly • Level 2 Fly • Full Fly • Hush Fly • Ball of Flies • Spider • Big Spider • Trite • Ragling • Rag Trite • Level 2 Spider • Ticking Spider • Baby Long Legs • Crazy Long Legs • Wall Creep • Blind Creep • Rage Creep • Para-Bite • Cod Worm • Scarred Para-Bite • Round Worm • Nightcrawler • Roundy • Ulcer • Maggot • Charger • Spitty • Conjoined Spitty • Drowned Charger • Grub • Clotty • Clot • Mega Clotty • Leech • Kamikaze Leech • Holy Leech
Objects
Boil • Gut • Sack • Blue Boil • Host • Red Host • Wall Hugger • Slide • Poky • Stone Grimace • Vomit Grimace • Gaping Maw • Turret Grimace • Brimstone Grimace
Humanoids
Mulligan • Mulligoon • Mulliboom • Hive • Swarmer • Nest • Drowned Hive • Hopper • Flaming Hopper • Leaper • Pacer • Gusher • Splasher • Gaper • Frowning Gaper • Gurgle • Mr. Maw • Flaming Gaper • Cyclopia • Skinny • Rotty • Null • Greed Gaper • Blue Gaper • Swinger • Horf • Psychic Horf • Globin • Gazing Globin • Black Globin • Dank Globin • Knight • Selfless Knight • Floating Knight • Bone Knight • Bony • Black Bony • Fatty • Flaming Fatty • Conjoined Fatty • Blue Conjoined Fatty • Pale Fatty • Keeper • Hanger • Vis • Double Vis • Chubber • Cage Vis • Scarred Double Vis • Homunculus • Begotten • Dople • Evil Twin
Body parts
Mask + Heart • Brain • MemBrain • Guts • Mama Guts • Eye • Bloodshot Eye • Mom's Hand • Dead Mom's Hand • Scarred Guts • Nerve Ending • Stone Eye
Poop
Dip • Corn Dip • Brown Dip • Squirt • Dank Squirt • Dinga
Flyers
Maw • Red Maw • Psychic Maw • Death's Head • Dank Death's Head • Flesh Death's Head • Lil' Haunt • Wizoob • Red Ghost • One Tooth • Fat Bat • Tumor • Psy Tumor • Camillo Jr. • Baby • Angelic Baby • Imp • Dukie • Oob • Black Maw
Others
Fred • Lump • Embryo • B. Licker