Bob's Brain is an item in The Binding of Isaac: Rebirth. It is a floating green brain-like object.
It launches in the direction he is shooting and explodes if it hits an enemy, poisoning nearby enemies (and also the player if they are in the item's range, it can also open secret rooms upon exploding just like normal bombs), similarly to IPECAC and Bob's Rotten Head. Once it explodes, it reappears after several seconds.
Bob's Brain appears in the first treasure room using the following seed(s):
- JNB7 SDQD
- ZAK4 P4T7
- 77JY BFBP
- DT2Z X7TG