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For other uses, see Fly (disambiguation).

Black Flies are very common enemies, found in almost all floors. They can first naturally spawn in The Basement, and also come in sort of multiple variants.

Behavior

Black flies buzz around the room randomly, often moving away from the player. They cannot damage Isaac at all, even by touch, making them completely harmless. However, they can turn into relatively dangerous Pooters if they fly around Poop for too long.

Trivia

  • During the credits, the Black Fly, Psychic Maw, and Embryo's images are the only monsters that are animated.
  • Black Flies, along with other type of flies, are one of the enemies with lack of champion variants.
    • Same apply to Spiders and few other monsters.
Monsters
Fly variants FlyBlack FlyCUSTOMredflyAttack FlyMotersMoter • (Wrath of the Lamb DLC: White flyEternal Fly)
Gaper variants GaperGaperFrowninggaperFrowning GaperShape4336Mr. Maw • (Wrath of the Lamb DLC: Green gaperGurgle)
Mulligan variants MulliganMulliganMulligoonMulligoonHiveHive • (Wrath of the Lamb DLC: MulliboomMulliboom)
Horf variants HorfsHorfMawsMawRedmawRed Maw • (Wrath of the Lamb DLC: PsychicmawPsychic Maw)
Vis variants VisVis • (Wrath of the Lamb DLC: Vis FioDouble VisChubby VisChubber)
Maggot variants MaggotMaggotChargerChargerSpitySpitty
Hopper variants HopperHopperFHopperFlaming HopperLeaperLeaper
Boil variants BoilBoil • (Wrath of the Lamb DLC: Green boilGutWhite boilSack)
Clot variants ClottyClottyClot2ClotBlockadeI. Blob
Leech variants LeechLeechLeech2Kamikaze Leech • (Wrath of the Lamb DLC: Holy leechHoly Leech)
Spider variants Wrath of the Lamb DLC: Black spiderSpiderBig spiderBig SpiderSpider hopperTrite
Pooter variants PouterPooter • (Wrath of the Lamb DLC: SuperpooterFat Fly)
Boomfly variants BoomflyBoom FlySpitflyRed Boom Fly
Pacer variants PacerPacerGusherGusher
Sucker variants SuckerSucker • (Wrath of the Lamb DLC: PufferSpit)
Globin variants GlobinGlobinGlobin 2Gazing Globin
Knight variants KnightsKnightAlternative knightSelfless Knight
Eye variants EyeEyeEye2Bloodshot Eye
Host variants Host1HostHost2Red Host
Baby variants BobyBaby • (Wrath of the Lamb DLC: Angel babyAngelic Baby)
Eye variants EyeEyeEye2Bloodshot Eye
Poky variants PokiesPoky • (Wrath of the Lamb DLC: Spike trapSlide)
Brain variants BrainBrainMembrainMembrain
Gut variants GutsMonsterGuts • (Wrath of the Lamb DLC: Big gutsMama Guts)
Dople variants Dople1DopleDople 2Evil Twin
Grimace variants TurretStone Grimace • (Wrath of the Lamb DLC: VomitTurretVomit Grimace)
Keeper variants Wrath of the Lamb DLC: AvariceKeeperHang manHanger
Standalone variants ParabitePara-BiteFredFredLumpLumpEmbryoEmbryoPeep Eye • (Wrath of the Lamb DLC: SwarmheadSwarmerMask HeartMask + HeartCentipedeB. Licker)
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